Application domain
PPGL (Pheochromocytomas and Paragangliomas) refers to rare neuroendocrine tumors that can develop in the adrenal medulla or along the sympathetic nervous system. These tumors secrete catecholamines, causing symptoms like high blood pressure, headaches, and palpitations. While some PPGLs are benign, all have the potential to metastasize, and diagnosis often involves genetic testing, imaging, and measuring catecholamine metabolites. Treatment depends on the tumor's stage and molecular characteristics, and ongoing research focuses on targeted therapies for metastatic disease.
Project B12 Neural-crest derived catecholamine producing tumours: implementation of molecular and metabolic fingerprints to predict disease progression and therapeutic response…
A cross-domain workbench for building, explaining and — critically — validating AI models before anyone trusts them. It couples model…
Utility of disease probability scores to guide decision-making during screening for phaeochromocytoma and paraganglioma: a machine learning modelling cross sectional…
eClinicalMedicine — Vol. 82, pp. 103181 10.1016/j.eclinm.2025.103181
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