Pheochromocytomas and Paragangliomas

PPGL (Pheochromocytomas and Paragangliomas) refers to rare neuroendocrine tumors that can develop in the adrenal medulla or along the sympathetic nervous system. These tumors secrete catecholamines, causing symptoms like high blood pressure, headaches, and palpitations. While some PPGLs are benign, all have the potential to metastasize, and diagnosis often involves genetic testing, imaging, and measuring catecholamine metabolites. Treatment depends on the tumor's stage and molecular characteristics, and ongoing research focuses on targeted therapies for metastatic disease.